7CL8

Testosterone-bound structure of CYP154C2 from Streptomyces avermitilis in an closed conformation

7CL8 の概要

• エントリーDOI: 10.2210/pdb7cl8/pdb
• 分子名称: Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, TRIETHYLENE GLYCOL, ... (6 entities in total)
• 機能のキーワード: cytochrome p450, hydroxylase, testosterone, oxidoreductase
• 由来する生物種: Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46539.74

構造登録者

Xu, L.H.,Fushinobu, S. (登録日: 2020-07-20, 公開日: 2021-07-21, 最終更新日: 2023-11-29)

• 主引用文献: Gao, Q.,Ma, B.,Wang, Q.,Zhang, H.,Fushinobu, S.,Yang, J.,Lin, S.,Sun, K.,Han, B.N.,Xu, L.H.; Improved 2 alpha-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design.; Appl.Environ.Microbiol., 89:e0218622-e0218622, 2023; PubMed: 36847541; DOI: 10.1128/aem.02186-22

実験手法

X-RAY DIFFRACTION (1.42 Å)