7CI6

Crystal structure of P.aeruginosa LpxC in complex with inhibitor

Summary for 7CI6

Entry DOI	10.2210/pdb7ci6/pdb
Descriptor	UDP-3-O-acyl-N-acetylglucosamine deacetylase, (1S)-1-[1-[3-(4-chlorophenyl)propyl]imidazol-2-yl]ethanol, ZINC ION, ... (5 entities in total)
Functional Keywords	udp-3-o-acyl-n-acetylglucosamine deacetylase, enva, lpxc, pseudomonas aeruginosa, hydrolase
Biological source	Pseudomonas aeruginosa PAO1
Total number of polymer chains	2
Total formula weight	67024.46
Authors	Mima, M.,Baker, L.M.,Surgenor, A.,Robertson, A. (deposition date: 2020-07-07, release date: 2020-12-02, Last modification date: 2023-11-29)
Primary citation	Yamada, Y.,Takashima, H.,Walmsley, D.L.,Ushiyama, F.,Matsuda, Y.,Kanazawa, H.,Yamaguchi-Sasaki, T.,Tanaka-Yamamoto, N.,Yamagishi, J.,Kurimoto-Tsuruta, R.,Ogata, Y.,Ohtake, N.,Angove, H.,Baker, L.,Harris, R.,Macias, A.,Robertson, A.,Surgenor, A.,Watanabe, H.,Nakano, K.,Mima, M.,Iwamoto, K.,Okada, A.,Takata, I.,Hitaka, K.,Tanaka, A.,Fujita, K.,Sugiyama, H.,Hubbard, R.E. Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity. J.Med.Chem., 63:14805-14820, 2020 Cited by PubMed: 33210531 DOI: 10.1021/acs.jmedchem.0c01215 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation