7CEU

Crystal structure of L-cycloserine-bound form of cysteine desulfurase NifS from Helicobacter pylori

Summary for 7CEU

• Entry DOI: 10.2210/pdb7ceu/pdb
• Descriptor: Cysteine desulfurase IscS, ISOPROPYL ALCOHOL, (5-hydroxy-6-methyl-4-{[(3-oxo-2,3-dihydro-1,2-oxazol-4-yl)amino]methyl}pyridin-3-yl)methyl dihydrogen phosphate, ... (4 entities in total)
• Functional Keywords: cysteine desulfurase, plp-dependent enzyme, cysteine metabolism, cycloserine, inhibitor, fe-s cluster biosynthesis, biosynthetic protein
• Biological source: Helicobacter pylori 26695
• Total number of polymer chains: 1
• Total formula weight: 44516.54

Authors

Nakamura, R.,Takahashi, Y.,Fujishiro, T. (deposition date: 2020-06-24, release date: 2021-06-30, Last modification date: 2023-11-29)

• Primary citation: Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T.; Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms.; Febs J., 2022; PubMed: 35395703; DOI: 10.1111/febs.16455

Experimental method

X-RAY DIFFRACTION (2.9 Å)