7CDE
Crystal structure of LSD1-CoREST in complex with PRSFLVRKR peptide
Summary for 7CDE
Entry DOI | 10.2210/pdb7cde/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, PRO-ARG-SER-PHE-LEU-VAL-ARG-LYS-ARG, ... (6 entities in total) |
Functional Keywords | demethylase, amine oxidase, chromatin, histone, fad, corepressor, oxidoreductase-transcription-inhibitor complex, oxidoreductase, oxidoreductase-transcription complex, oxidoreductase/transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 92592.42 |
Authors | Kikuchi, M.,Kitagawa, H.,Sato, S.,Umezawa, N.,Higuchi, T.,Umehara, T. (deposition date: 2020-06-19, release date: 2021-06-23, Last modification date: 2023-11-29) |
Primary citation | Kitagawa, H.,Kikuchi, M.,Sato, S.,Watanabe, H.,Umezawa, N.,Kato, M.,Hisamatsu, Y.,Umehara, T.,Higuchi, T. Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity. J.Med.Chem., 64:3707-3719, 2021 Cited by PubMed: 33754721DOI: 10.1021/acs.jmedchem.0c01371 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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