7CCY

Crystal structure of the 2-iodoporphobilinogen-bound holo form of human hydroxymethylbilane synthase

7CCY の概要

• エントリーDOI: 10.2210/pdb7ccy/pdb
• 分子名称: Porphobilinogen deaminase, 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid, 3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid, ... (4 entities in total)
• 機能のキーワード: porphyrin synthesis, inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79958.98

構造登録者

Sato, H.,Sugishima, M.,Wada, K.,Hirabayashi, K.,Tsukaguchi, M. (登録日: 2020-06-18, 公開日: 2021-03-17, 最終更新日: 2023-11-29)

• 主引用文献: Sato, H.,Sugishima, M.,Tsukaguchi, M.,Masuko, T.,Iijima, M.,Takano, M.,Omata, Y.,Hirabayashi, K.,Wada, K.,Hisaeda, Y.,Yamamoto, K.; Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.; Biochem.J., 478:1023-1042, 2021; PubMed: 33600566; DOI: 10.1042/BCJ20200996

実験手法

X-RAY DIFFRACTION (2.4 Å)