7CBT
The crystal structure of SARS-CoV-2 main protease in complex with GC376
Summary for 7CBT
Entry DOI | 10.2210/pdb7cbt/pdb |
Descriptor | 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total) |
Functional Keywords | sars-cov-2, main protease, gc376, complex, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 2 |
Total formula weight | 74798.81 |
Authors | |
Primary citation | Shi, Y.,Shuai, L.,Wen, Z.,Wang, C.,Yan, Y.,Jiao, Z.,Guo, F.,Fu, Z.F.,Chen, H.,Bu, Z.,Peng, G. The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract. Emerg Microbes Infect, 10:481-492, 2021 Cited by PubMed: 33691601DOI: 10.1080/22221751.2021.1899770 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.346 Å) |
Structure validation
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