7CBT

The crystal structure of SARS-CoV-2 main protease in complex with GC376

7CBT の概要

• エントリーDOI: 10.2210/pdb7cbt/pdb
• 分子名称: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total)
• 機能のキーワード: sars-cov-2, main protease, gc376, complex, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74798.81

構造登録者

Shi, Y.,Peng, G. (登録日: 2020-06-13, 公開日: 2020-09-02, 最終更新日: 2023-11-29)

• 主引用文献: Shi, Y.,Shuai, L.,Wen, Z.,Wang, C.,Yan, Y.,Jiao, Z.,Guo, F.,Fu, Z.F.,Chen, H.,Bu, Z.,Peng, G.; The preclinical inhibitor GS441524 in combination with GC376 efficaciously inhibited the proliferation of SARS-CoV-2 in the mouse respiratory tract.; Emerg Microbes Infect, 10:481-492, 2021; PubMed: 33691601; DOI: 10.1080/22221751.2021.1899770

実験手法

X-RAY DIFFRACTION (2.346 Å)