7CBG
Crystal structure of threonyl-tRNA synthetase (ThrRS) from Salmonella enterica in complex with an inhibitor
Summary for 7CBG
Entry DOI | 10.2210/pdb7cbg/pdb |
Descriptor | Threonine--tRNA ligase, (2S,3R)-N-[(E)-4-[6,7-bis(chloranyl)-4-oxidanylidene-quinazolin-3-yl]but-2-enyl]-2-(methylamino)-3-oxidanyl-butanamide, ZINC ION, ... (4 entities in total) |
Functional Keywords | ligase-inhibitor complex, ligase/inhibitor |
Biological source | Salmonella enterica subsp. enterica serovar Cubana str. 76814 |
Total number of polymer chains | 2 |
Total formula weight | 96858.39 |
Authors | |
Primary citation | Guo, J.,Chen, B.,Yu, Y.,Cheng, B.,Ju, Y.,Tang, J.,Cai, Z.,Gu, Q.,Xu, J.,Zhou, H. Structure-guided optimization and mechanistic study of a class of quinazolinone-threonine hybrids as antibacterial ThrRS inhibitors. Eur.J.Med.Chem., 207:112848-112848, 2020 Cited by PubMed: 32980741DOI: 10.1016/j.ejmech.2020.112848 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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