7CB7

1.7A resolution structure of SARS-CoV-2 main protease (Mpro) in complex with broad-spectrum coronavirus protease inhibitor GC376

7CB7 の概要

• エントリーDOI: 10.2210/pdb7cb7/pdb
• 分子名称: 3C-like proteinase, SODIUM ION, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (5 entities in total)
• 機能のキーワード: main protease, 3c-like proteinase, protein-inhibitor complex, gc376, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70246.85

構造登録者

Wang, Y.C.,Yang, C.S.,Hou, M.H.,Tsai, C.L.,Chou, Y.Z.,Chen, Y.,Hung, M.C. (登録日: 2020-06-10, 公開日: 2021-05-05, 最終更新日: 2023-11-29)

• 主引用文献: Wang, Y.C.,Yang, W.H.,Yang, C.S.,Hou, M.H.,Tsai, C.L.,Chou, Y.Z.,Hung, M.C.,Chen, Y.; Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug.; Am J Cancer Res, 10:2535-2545, 2020; PubMed: 32905393

実験手法

X-RAY DIFFRACTION (1.69 Å)