7CA1

Crystal structure of dihydroorotase in complex with plumbagin from Saccharomyces cerevisiae

Summary for 7CA1

• Entry DOI: 10.2210/pdb7ca1/pdb
• Related: 6L0A 6L0B
• Descriptor: Dihydroorotase, (2S)-2-hydroxybutanedioic acid, ZINC ION, ... (4 entities in total)
• Functional Keywords: dihydropyrimidinase, dihydroorotase, metalloenzyme, hydrolase
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
• Total number of polymer chains: 4
• Total formula weight: 167081.22

Authors

Guan, H.H.,Huang, Y.H.,Huang, C.Y.,Chen, C.J. (deposition date: 2020-06-08, release date: 2021-06-09, Last modification date: 2023-11-29)

• Primary citation: Guan, H.H.,Huang, Y.H.,Lin, E.S.,Chen, C.J.,Huang, C.Y.; Plumbagin, a Natural Product with Potent Anticancer Activities, Binds to and Inhibits Dihydroorotase, a Key Enzyme in Pyrimidine Biosynthesis.; Int J Mol Sci, 22:-, 2021; PubMed: 34202294; DOI: 10.3390/ijms22136861

Experimental method

X-RAY DIFFRACTION (3.6 Å)