7C53

Crystal Structure of SARS-CoV-2 HR1 motif in complex with pan-CoVs inhibitor EK1

7C53 の概要

• エントリーDOI: 10.2210/pdb7c53/pdb
• 分子名称: Spike protein S2',pan-CoVs inhibitor EK1, CALCIUM ION (3 entities in total)
• 機能のキーワード: sars-cov-2 hr1, pan-covs inhibitor, ek1 peptide, virus, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 70040.53

構造登録者

Zhu, Y.,Yang, X.,Sun, F. (登録日: 2020-05-19, 公開日: 2021-05-19, 最終更新日: 2023-11-29)

• 主引用文献: Xia, S.,Lan, Q.,Zhu, Y.,Wang, C.,Xu, W.,Li, Y.,Wang, L.,Jiao, F.,Zhou, J.,Hua, C.,Wang, Q.,Cai, X.,Wu, Y.,Gao, J.,Liu, H.,Sun, G.,Munch, J.,Kirchhoff, F.,Yuan, Z.,Xie, Y.,Sun, F.,Jiang, S.,Lu, L.; Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation.; Signal Transduct Target Ther, 6:288-288, 2021; PubMed: 34326308; DOI: 10.1038/s41392-021-00712-2

実験手法

X-RAY DIFFRACTION (2.278 Å)