7C4V

MicroED structure of anorthic Vancomycin at 1.05 A resolution

7C4V の概要

• エントリーDOI: 10.2210/pdb7c4v/pdb
• EMDBエントリー: 30289
• 関連するBIRD辞書のPRD_ID: PRD_000204
• 分子名称: Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: microed, vancomycin, superbacteria, antibiotic
• 由来する生物種: Amycolatopsis orientalis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 2982.09

構造登録者

Fan, Q.,Zhou, H.,Li, X.,Wang, J. (登録日: 2020-05-18, 公開日: 2020-08-12, 最終更新日: 2023-11-29)

主引用文献

Fan, Q.,Li, L.,Xue, H.,Zhou, H.,Zhao, L.,Liu, J.,Mao, J.,Wu, S.,Zhang, S.,Wu, C.,Li, X.,Zhou, X.,Wang, J.
Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms.
Angew.Chem.Int.Ed.Engl., 59:15141-15146, 2020

PubMed Abstract: It has been long-pursued but remains a challenge to precisely manipulate the molecular assembly process to obtain desired functional structures. Reported here is the control over the assembly of solute molecules, by a programmed recrystallization of solvent crystal grains, to form micro/nanoparticles with tunable sizes and crystalline forms. A quantitative correlation between the protocol of recrystallization temperature and the assembly kinetics results in precise control over the size of assembled particles, ranging from single-atom catalysts, pure drug nanoparticles, to sub-millimeter organic-semiconductor single crystals. The extensive regulation of the assembly rates leads to the unique and powerful capability of tuning the stacking of molecules, involving the formation of single crystals of notoriously crystallization-resistant molecules and amorphous structures of molecules with a very high propensity to crystallize, which endows it with wide-ranging applications.

PubMed: 32432368
DOI: 10.1002/anie.202003922

実験手法

ELECTRON CRYSTALLOGRAPHY (1.05 Å)