7C2M

Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with NITD-349

7C2M の概要

• エントリーDOI: 10.2210/pdb7c2m/pdb
• 分子名称: Chimera of drug exporters of the RND superfamily-like protein and Endolysin, N-(4,4-dimethylcyclohexyl)-4,6-bis(fluoranyl)-1H-indole-2-carboxamide, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ... (4 entities in total)
• 機能のキーワード: membrane protein
• 由来する生物種: Mycolicibacterium smegmatis MC2 155; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 106246.23

構造登録者

Zhang, B.,Yang, X.,Hu, T.,Rao, Z. (登録日: 2020-05-08, 公開日: 2020-12-02, 最終更新日: 2023-11-29)

• 主引用文献: Yang, X.,Hu, T.,Yang, X.,Xu, W.,Yang, H.,Guddat, L.W.,Zhang, B.,Rao, Z.; Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO.; J.Mol.Biol., 432:4426-4434, 2020; PubMed: 32512002; DOI: 10.1016/j.jmb.2020.05.019

実験手法

X-RAY DIFFRACTION (3.1 Å)