7C2I

Crystal structure of nsp16-nsp10 heterodimer from SARS-CoV-2 in complex with SAM (with additional SAM during crystallization)

7C2I の概要

• エントリーDOI: 10.2210/pdb7c2i/pdb
• 分子名称: 2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYLMETHIONINE, ... (5 entities in total)
• 機能のキーワード: 2'-o-methylase, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50058.96

構造登録者

Lin, S.,Chen, H.,Ye, F.,Chen, Z.M.,Yang, F.L.,Zheng, Y.,Cao, Y.,Qiao, J.X.,Yang, S.Y.,Lu, G.W. (登録日: 2020-05-07, 公開日: 2020-05-27, 最終更新日: 2023-11-29)

• 主引用文献: Lin, S.,Chen, H.,Ye, F.,Chen, Z.,Yang, F.,Zheng, Y.,Cao, Y.,Qiao, J.,Yang, S.,Lu, G.; Crystal structure of SARS-CoV-2 nsp10/nsp16 2'-O-methylase and its implication on antiviral drug design.; Signal Transduct Target Ther, 5:131-131, 2020; PubMed: 32728018; DOI: 10.1038/s41392-020-00241-4

実験手法

X-RAY DIFFRACTION (2.5 Å)