7C2E
GLP-1R-Gs complex structure with a small molecule full agonist
Summary for 7C2E
Entry DOI | 10.2210/pdb7c2e/pdb |
EMDB information | 30274 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | gpcr, cryoem, glp-1, membrane protein |
Biological source | Homo sapiens More |
Total number of polymer chains | 5 |
Total formula weight | 164522.37 |
Authors | Ma, H.,Yuan, D.P.,Huang, W.,Wenge, Z.,Xu, E. (deposition date: 2020-05-07, release date: 2020-08-26, Last modification date: 2024-11-20) |
Primary citation | Ma, H.,Huang, W.,Wang, X.,Zhao, L.,Jiang, Y.,Liu, F.,Guo, W.,Sun, X.,Zhong, W.,Yuan, D.,Xu, H.E. Structural insights into the activation of GLP-1R by a small molecule agonist. Cell Res., 30:1140-1142, 2020 Cited by PubMed: 32724086DOI: 10.1038/s41422-020-0384-8 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.2 Å) |
Structure validation
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