7BY6
Plasmodium vivax cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD1389
Summary for 7BY6
Entry DOI | 10.2210/pdb7by6/pdb |
Descriptor | Phenylalanyl-tRNA synthetase beta chain, putative, (3S,4R,8R,9R,10S)-N-(4-cyclopropyloxyphenyl)-10-(methoxymethyl)-3,4-bis(oxidanyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | aminoacylation, aminoacyl-trna synthetase, trna-binding, atp-binding, auxiliary pocket, heterotetrameric, ligase |
Biological source | Plasmodium vivax More |
Total number of polymer chains | 2 |
Total formula weight | 107447.67 |
Authors | Malhotra, N.,Manmohan, S.,Harlos, K.,Melillo, B.,Schreiber, S.L.,Manickam, Y.,Sharma, S. (deposition date: 2020-04-21, release date: 2020-11-04, Last modification date: 2023-11-29) |
Primary citation | Sharma, M.,Malhotra, N.,Yogavel, M.,Harlos, K.,Melillo, B.,Comer, E.,Gonse, A.,Parvez, S.,Mitasev, B.,Fang, F.G.,Schreiber, S.L.,Sharma, A. Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines. Nat Commun, 12:343-343, 2021 Cited by PubMed: 33436639DOI: 10.1038/s41467-020-20478-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.997 Å) |
Structure validation
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