7BY6

Plasmodium vivax cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD1389

7BY6 の概要

• エントリーDOI: 10.2210/pdb7by6/pdb
• 分子名称: Phenylalanyl-tRNA synthetase beta chain, putative, (3S,4R,8R,9R,10S)-N-(4-cyclopropyloxyphenyl)-10-(methoxymethyl)-3,4-bis(oxidanyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: aminoacylation, aminoacyl-trna synthetase, trna-binding, atp-binding, auxiliary pocket, heterotetrameric, ligase
• 由来する生物種: Plasmodium vivax; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107447.67

構造登録者

Malhotra, N.,Manmohan, S.,Harlos, K.,Melillo, B.,Schreiber, S.L.,Manickam, Y.,Sharma, S. (登録日: 2020-04-21, 公開日: 2020-11-04, 最終更新日: 2023-11-29)

• 主引用文献: Sharma, M.,Malhotra, N.,Yogavel, M.,Harlos, K.,Melillo, B.,Comer, E.,Gonse, A.,Parvez, S.,Mitasev, B.,Fang, F.G.,Schreiber, S.L.,Sharma, A.; Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.; Nat Commun, 12:343-343, 2021; PubMed: 33436639; DOI: 10.1038/s41467-020-20478-5

実験手法

X-RAY DIFFRACTION (2.997 Å)