7BVC

Cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase EmbA-EmbB-AcpM2 in complex with ethambutol

7BVC の概要

• エントリーDOI: 10.2210/pdb7bvc/pdb
• EMDBエントリー: 30216
• 分子名称: Integral membrane indolylacetylinositol arabinosyltransferase EmbA, Integral membrane indolylacetylinositol arabinosyltransferase EmbB, Meromycolate extension acyl carrier protein, ... (9 entities in total)
• 機能のキーワード: mycobacterium smegmatis, cell wall synthesis, drug target, ethambutol, arabinosyltransferase, emba, embb, embc, acyl carrier protein, arabinogalactan, lipoarabinomannan, drug resistance, transferase
• 由来する生物種: Mycolicibacterium smegmatis MC2 155; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 250960.60

構造登録者

Zhang, L.,Zhao, Y.,Gao, Y.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z. (登録日: 2020-04-10, 公開日: 2020-04-29, 最終更新日: 2020-07-01)

• 主引用文献: Zhang, L.,Zhao, Y.,Gao, Y.,Wu, L.,Gao, R.,Zhang, Q.,Wang, Y.,Wu, C.,Wu, F.,Gurcha, S.S.,Veerapen, N.,Batt, S.M.,Zhao, W.,Qin, L.,Yang, X.,Wang, M.,Zhu, Y.,Zhang, B.,Bi, L.,Zhang, X.,Yang, H.,Guddat, L.W.,Xu, W.,Wang, Q.,Li, J.,Besra, G.S.,Rao, Z.; Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol.; Science, 368:1211-1219, 2020; PubMed: 32327601; DOI: 10.1126/science.aba9102

実験手法

ELECTRON MICROSCOPY (2.9 Å)