7BUY

The crystal structure of COVID-19 main protease in complex with carmofur

7BUY の概要

• エントリーDOI: 10.2210/pdb7buy/pdb
• 分子名称: 3C-like proteinase, hexylcarbamic acid, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: covid-2019 virus, main protease, carmofur, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34361.41

構造登録者

Zhao, Y.,Zhang, B.,Jin, Z.,Liu, X.,Yang, H.,Rao, Z. (登録日: 2020-04-08, 公開日: 2020-04-29, 最終更新日: 2023-11-29)

• 主引用文献: Jin, Z.,Zhao, Y.,Sun, Y.,Zhang, B.,Wang, H.,Wu, Y.,Zhu, Y.,Zhu, C.,Hu, T.,Du, X.,Duan, Y.,Yu, J.,Yang, X.,Yang, X.,Yang, K.,Liu, X.,Guddat, L.W.,Xiao, G.,Zhang, L.,Yang, H.,Rao, Z.; Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.; Nat.Struct.Mol.Biol., 27:529-532, 2020; PubMed: 32382072; DOI: 10.1038/s41594-020-0440-6

実験手法

X-RAY DIFFRACTION (1.6 Å)