7BO6
VDR complex with LCA derivative
Summary for 7BO6
Entry DOI | 10.2210/pdb7bo6/pdb |
Descriptor | Vitamin D3 receptor A, Nuclear receptor coactivator 1, (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-(2-methyl-2-oxidanyl-propyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid, ... (4 entities in total) |
Functional Keywords | nuclear receptor, agonist, transcription |
Biological source | Danio rerio (Zebrafish) More |
Total number of polymer chains | 2 |
Total formula weight | 36269.42 |
Authors | Rochel, N. (deposition date: 2021-01-24, release date: 2021-08-11, Last modification date: 2024-01-31) |
Primary citation | Gaikwad, S.,Gonzalez, C.M.,Vilarino, D.,Lasanta, G.,Villaverde, C.,Mourino, A.,Verlinden, L.,Verstuyf, A.,Peluso-Iltis, C.,Rochel, N.,Berkowska, K.,Marcinkowska, E. Lithocholic acid-based design of noncalcemic vitamin D receptor agonists. Bioorg.Chem., 111:104878-104878, 2021 Cited by PubMed: 33853023DOI: 10.1016/j.bioorg.2021.104878 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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