7BES
CryoEM structure of Mycobacterium tuberculosis UMP Kinase (UMPK) in complex with UDP and UTP
Summary for 7BES
Entry DOI | 10.2210/pdb7bes/pdb |
EMDB information | 12158 |
Descriptor | Uridylate kinase, URIDINE-5'-DIPHOSPHATE, URIDINE 5'-TRIPHOSPHATE (3 entities in total) |
Functional Keywords | nucleotide metabolism, ump kinase, allosteric regulation, antibacterial target, transferase |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 3 |
Total formula weight | 91058.44 |
Authors | Bous, J.,Trapani, S.,Walter, P.,Bron, P.,Munier-Lehmann, H. (deposition date: 2020-12-24, release date: 2022-01-12, Last modification date: 2024-07-10) |
Primary citation | Walter, P.,Mechaly, A.,Bous, J.,Haouz, A.,England, P.,Lai-Kee-Him, J.,Ancelin, A.,Hoos, S.,Baron, B.,Trapani, S.,Bron, P.,Labesse, G.,Munier-Lehmann, H. Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target. Febs J., 289:4869-4887, 2022 Cited by PubMed: 35152545DOI: 10.1111/febs.16393 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.85 Å) |
Structure validation
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