7BEA

Structure of human Programmed cell death 1 ligand 1 (PD-L1) with inhibitor

Summary for 7BEA

• Entry DOI: 10.2210/pdb7bea/pdb
• Descriptor: Programmed cell death 1 ligand 1, 2-(aminomethyl)-6-[(2-methyl-3-phenyl-phenyl)methoxy]-~{N}-(2-phenylethyl)imidazo[1,2-a]pyridin-3-amine (3 entities in total)
• Functional Keywords: pd-l1, immune checkpoint, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29820.10

Authors

Magiera-Mularz, K.,Butera, R.,Wazynska, M.,Holak, T.,Domling, A. (deposition date: 2020-12-22, release date: 2021-06-09, Last modification date: 2024-01-31)

• Primary citation: Butera, R.,Wazynska, M.,Magiera-Mularz, K.,Plewka, J.,Musielak, B.,Surmiak, E.,Sala, D.,Kitel, R.,de Bruyn, M.,Nijman, H.W.,Elsinga, P.H.,Holak, T.A.,Domling, A.; Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists.; Acs Med.Chem.Lett., 12:768-773, 2021; PubMed: 34055224; DOI: 10.1021/acsmedchemlett.1c00033

Experimental method

X-RAY DIFFRACTION (2.45 Å)