7BCM

The DDR1 Kinase Domain Bound To SR302

Summary for 7BCM

• Entry DOI: 10.2210/pdb7bcm/pdb
• Descriptor: Epithelial discoidin domain-containing receptor 1, ~{N}-[[4-[[(2~{S})-4-cyclohexyl-1-[[(3~{S})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide (3 entities in total)
• Functional Keywords: kinase cancer inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 72753.74

Authors

Mathea, S.,Chatterjee, D.,Preuss, F.,Roehm, S.,Joerger, A.,Knapp, S. (deposition date: 2020-12-20, release date: 2021-03-03, Last modification date: 2024-01-31)

• Primary citation: Rohm, S.,Berger, B.T.,Schroder, M.,Chatterjee, D.,Mathea, S.,Joerger, A.C.,Pinkas, D.M.,Bufton, J.C.,Tjaden, A.,Kovooru, L.,Kudolo, M.,Pohl, C.,Bullock, A.N.,Muller, S.,Laufer, S.,Knapp, S.; Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe.; J.Med.Chem., 64:13451-13474, 2021; PubMed: 34506142; DOI: 10.1021/acs.jmedchem.1c00868

Experimental method

X-RAY DIFFRACTION (2.3 Å)