7BBH

Structure of Coronavirus Spike from Smuggled Guangdong Pangolin

Summary for 7BBH

• Entry DOI: 10.2210/pdb7bbh/pdb
• EMDB information: 12130
• Descriptor: Surface glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: coronavirus, pangolin, spike, smuggled, dsp, viral protein
• Biological source: Pangolin coronavirus
• Total number of polymer chains: 3
• Total formula weight: 430268.26

Authors

Wrobel, A.G.,Benton, D.J.,Rosenthal, P.B.,Gamblin, S.J. (deposition date: 2020-12-17, release date: 2020-12-30, Last modification date: 2024-11-13)

Primary citation

Wrobel, A.G.,Benton, D.J.,Xu, P.,Calder, L.J.,Borg, A.,Roustan, C.,Martin, S.R.,Rosenthal, P.B.,Skehel, J.J.,Gamblin, S.J.
Structure and binding properties of Pangolin-CoV spike glycoprotein inform the evolution of SARS-CoV-2.
Nat Commun, 12:837-837, 2021

PubMed Abstract: Coronaviruses of bats and pangolins have been implicated in the origin and evolution of the pandemic SARS-CoV-2. We show that spikes from Guangdong Pangolin-CoVs, closely related to SARS-CoV-2, bind strongly to human and pangolin ACE2 receptors. We also report the cryo-EM structure of a Pangolin-CoV spike protein and show it adopts a fully-closed conformation and that, aside from the Receptor-Binding Domain, it resembles the spike of a bat coronavirus RaTG13 more than that of SARS-CoV-2.

PubMed: 33547281
DOI: 10.1038/s41467-021-21006-9

Experimental method

ELECTRON MICROSCOPY (2.9 Å)