7B9O

Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S169 inhibitor

Summary for 7B9O

Entry DOI	10.2210/pdb7b9o/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 3-(5-(3,5-bis(trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)propanoic acid, ... (4 entities in total)
Functional Keywords	complex, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	27990.34
Authors	Ni, X.,Chaikuad, A.,Schierle, S.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-12-14, release date: 2021-02-10, Last modification date: 2024-01-31)
Primary citation	Schierle, S.,Chaikuad, A.,Lillich, F.F.,Ni, X.,Woltersdorf, S.,Schallmayer, E.,Renelt, B.,Ronchetti, R.,Knapp, S.,Proschak, E.,Merk, D. Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. J.Med.Chem., 64:5123-5136, 2021 Cited by PubMed: 33793232 DOI: 10.1021/acs.jmedchem.1c00235 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation