7B9O

Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with S169 inhibitor

7B9O の概要

• エントリーDOI: 10.2210/pdb7b9o/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 3-(5-(3,5-bis(trifluoromethyl)phenyl)-4-phenyloxazol-2-yl)propanoic acid, ... (4 entities in total)
• 機能のキーワード: complex, structural genomics, structural genomics consortium, sgc, dna binding protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27990.34

構造登録者

Ni, X.,Chaikuad, A.,Schierle, S.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-12-14, 公開日: 2021-02-10, 最終更新日: 2024-01-31)

• 主引用文献: Schierle, S.,Chaikuad, A.,Lillich, F.F.,Ni, X.,Woltersdorf, S.,Schallmayer, E.,Renelt, B.,Ronchetti, R.,Knapp, S.,Proschak, E.,Merk, D.; Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.; J.Med.Chem., 64:5123-5136, 2021; PubMed: 33793232; DOI: 10.1021/acs.jmedchem.1c00235

実験手法

X-RAY DIFFRACTION (2.05 Å)