7B93

Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A

Summary for 7B93

• Entry DOI: 10.2210/pdb7b93/pdb
• EMDB information: 12095
• Descriptor: NADH-ubiquinone oxidoreductase chain 3, NADH-ubiquinone oxidoreductase chain 6, NADH-ubiquinone oxidoreductase chain 4L, ... (55 entities in total)
• Functional Keywords: inhibitor, ubiquinone, complex i, oxidoreductase
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 45
• Total formula weight: 1072857.40

Authors

Chung, I.,Hirst, J. (deposition date: 2020-12-14, release date: 2021-05-26)

• Primary citation: Chung, I.,Serreli, R.,Cross, J.B.,Di Francesco, M.E.,Marszalek, J.R.,Hirst, J.; Cork-in-bottle mechanism of inhibitor binding to mammalian complex I.; Sci Adv, 7:-, 2021; PubMed: 33990335; DOI: 10.1126/sciadv.abg4000

Experimental method

ELECTRON MICROSCOPY (3.04 Å)