7B93
Cryo-EM structure of mitochondrial complex I from Mus musculus inhibited by IACS-2858 at 3.0 A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13251.8 | 1 | UniProt (P03899) Pfam (PF00507) | Mus musculus (Mouse) | NADH dehydrogenase subunit 3 |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 224 | 24715.9 | 1 | UniProt (Q9DC70) Pfam (PF01058) | Mus musculus (Mouse) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 263 | 30191.3 | 1 | UniProt (Q9DCT2) Pfam (PF00329) | Mus musculus (Mouse) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 4 | D (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52720.6 | 1 | UniProt (Q91WD5) Pfam (PF00346) | Mus musculus (Mouse) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 5 | E (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 248 | 27318.3 | 1 | UniProt (Q9D6J6) Pfam (PF01257) | Mus musculus (Mouse) | NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 6 | F (F) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50904.2 | 1 | UniProt (Q91YT0) Pfam (PF01512) Pfam (PF22461) Pfam (PF10589) | Mus musculus (Mouse) | Complex I-51kD,CI-51kD,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 7 | G (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79866.7 | 1 | UniProt (Q91VD9) Pfam (PF10588) Pfam (PF22117) Pfam (PF22151) Pfam (PF00384) Pfam (PF09326) Pfam (PF13510) | Mus musculus (Mouse) | Complex I-75kD,CI-75kD |
| 8 | H (H) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 36105.0 | 1 | UniProt (P03888) Pfam (PF00146) | Mus musculus (Mouse) | NADH dehydrogenase subunit 1 |
| 9 | I (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 24068.4 | 1 | UniProt (Q8K3J1) Pfam (PF12838) | Mus musculus (Mouse) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit |
| 10 | J (J) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 172 | 18656.1 | 1 | UniProt (P03925) Pfam (PF00499) | Mus musculus (Mouse) | NADH dehydrogenase subunit 6 |
| 11 | K (K) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10637.6 | 1 | UniProt (P03903) Pfam (PF00420) | Mus musculus (Mouse) | NADH dehydrogenase subunit 4L |
| 12 | L (L) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 607 | 68547.3 | 1 | UniProt (P03921) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) | Mus musculus (Mouse) | NADH dehydrogenase subunit 5 |
| 13 | M (M) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 51943.5 | 1 | UniProt (P03911) Pfam (PF01059) Pfam (PF00361) | Mus musculus (Mouse) | NADH dehydrogenase subunit 4 |
| 14 | N (N) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 345 | 38800.2 | 1 | UniProt (P03893) Pfam (PF00361) Pfam (PF06444) | Mus musculus (Mouse) | NADH dehydrogenase subunit 2 |
| 15 | O (O) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 355 | 40657.4 | 1 | UniProt (Q99LC3) Pfam (PF01712) | Mus musculus (Mouse) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 16 | P (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 377 | 42588.1 | 1 | UniProt (Q9DC69) Pfam (PF05368) | Mus musculus (Mouse) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 17 | Q (Q) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19814.7 | 1 | UniProt (Q9CXZ1) Pfam (PF04800) | Mus musculus (Mouse) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 18 | R (R) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 116 | 13041.8 | 1 | UniProt (P52503) Pfam (PF10276) | Mus musculus (Mouse) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 19 | S (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 10932.7 | 1 | UniProt (Q9CQ75) Pfam (PF05047) | Mus musculus (Mouse) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 20 | T, U (T, U) | Acyl carrier protein, mitochondrial | polymer | 156 | 17390.3 | 2 | UniProt (Q9CR21) Pfam (PF00550) | Mus musculus (Mouse) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 21 | V (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13380.7 | 1 | UniProt (Q9CPP6) Pfam (PF04716) | Mus musculus (Mouse) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 22 | W (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 131 | 15311.9 | 1 | UniProt (Q9CQZ5) Pfam (PF13233) | Mus musculus (Mouse) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 23 | X (X) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20025.1 | 1 | UniProt (Q9DCJ5) Pfam (PF06747) | Mus musculus (Mouse) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 24 | Y (Y) | MCG5603 | polymer | 143 | 15130.4 | 1 | UniProt (G5E814) Pfam (PF02466) | Mus musculus (Mouse) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 |
| 25 | Z (Z) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16881.6 | 1 | UniProt (Q9ERS2) Pfam (PF06212) | Mus musculus (Mouse) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic and interferon-induced mortality 19 protein,Gene associated with retinoic and IFN-induced mortality 19 protein,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 26 | AA (a) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8149.5 | 1 | UniProt (O35683) Pfam (PF15879) | Mus musculus (Mouse) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 27 | BA (b) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9338.9 | 1 | UniProt (Q9CQ91) Pfam (PF14987) | Mus musculus (Mouse) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 28 | CA (c) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8636.0 | 1 | UniProt (Q9CQY9) Pfam (PF15088) | Mus musculus (Mouse) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 29 | DA (d) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 120 | 14185.7 | 1 | UniProt (Q9CQ54) Pfam (PF06374) | Mus musculus (Mouse) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 30 | EA (e) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12675.8 | 1 | UniProt (Q99LY9) Pfam (PF10200) | Mus musculus (Mouse) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 31 | FA (f) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6965.1 | 1 | UniProt (P0DN34) Pfam (PF08040) | Mus musculus (Mouse) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 32 | GA (g) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 151 | 17463.7 | 1 | UniProt (O09111) Pfam (PF10183) | Mus musculus (Mouse) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit,Neuronal protein 15.6,p15.6 |
| 33 | HA (h) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21742.2 | 1 | UniProt (Q9CQH3) Pfam (PF09781) | Mus musculus (Mouse) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 34 | IA (i) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15540.1 | 1 | UniProt (Q3UIU2) Pfam (PF09782) | Mus musculus (Mouse) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 35 | JA (j) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 105 | 11982.4 | 1 | UniProt (Q9CPU2) Pfam (PF14813) | Mus musculus (Mouse) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 36 | KA (k) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 104 | 11714.2 | 1 | UniProt (Q9CQZ6) Pfam (PF08122) | Mus musculus (Mouse) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 37 | LA (l) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21903.8 | 1 | UniProt (Q9D6J5) Pfam (PF05821) | Mus musculus (Mouse) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 38 | MA (m) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15105.3 | 1 | UniProt (Q9CQC7) Pfam (PF07225) | Mus musculus (Mouse) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 39 | NA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 22020.1 | 1 | UniProt (Q9CQJ8) Pfam (PF05347) | Mus musculus (Mouse) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 40 | OA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16360.8 | 1 | UniProt (Q9CR61) Pfam (PF05676) | Mus musculus (Mouse) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 41 | PA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21054.8 | 1 | UniProt (Q9DCS9) Pfam (PF10249) | Mus musculus (Mouse) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 42 | QA (q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17154.5 | 1 | UniProt (Q7TMF3) Pfam (PF05071) | Mus musculus (Mouse) | Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2 |
| 43 | RA (r) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12637.6 | 1 | UniProt (Q9Z1P6) Pfam (PF07347) | Mus musculus (Mouse) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 44 | SA (s) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 104 | 11833.5 | 1 | UniProt (Q8BK30) Pfam (PF15880) | Mus musculus (Mouse) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 45 | AB, BB, IB, JB, TA... (G, I, B, F) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 46 | EB, HB, UA, VA (H, I, B) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 4 | Chemie (PC1) | |||
| 47 | AC, DB, GB, KB, LB... (i, H, I, K, L...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 9 | Chemie (3PE) | |||
| 48 | CB, XA (G, E) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 49 | YA (F) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 50 | FB (H) | 1-[[3-(4-methylsulfonylpiperidin-1-yl)phenyl]methyl]-5-[3-[4-(trifluoromethyloxy)phenyl]-1,2,4-oxadiazol-5-yl]pyridin-2-one | non-polymer | 574.6 | 1 | Chemie (T2Q) | |||
| 51 | BC, MB, OB, UB, WB... (q, L, N, X, d...) | CARDIOLIPIN | non-polymer | 1464.0 | 7 | Chemie (CDL) | |||
| 52 | PB (O) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 53 | QB (P) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 54 | RB (R) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 55 | SB, TB (T, U) | ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate | non-polymer | 584.7 | 2 | Chemie (EHZ) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 1046736.1 | |
| Non-Polymers* | Number of molecules | 35 |
| Total formula weight | 26121.3 | |
| All* | Total formula weight | 1072857.4 |
