7B7S

CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368

7B7S の概要

• エントリーDOI: 10.2210/pdb7b7s/pdb
• 分子名称: Cyclin-dependent kinase 2, Cyclin-A2, 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide, ... (7 entities in total)
• 機能のキーワード: cyclin-dependent kinase, flt3, acute myeloid leukemia, inhibition, cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128646.66

構造登録者

Djukic, S.,Skerlova, J.,Rezacova, P. (登録日: 2020-12-11, 公開日: 2021-08-04, 最終更新日: 2024-01-31)

• 主引用文献: Dayal, N.,Reznickova, E.,Hernandez, D.E.,Perina, M.,Torregrosa-Allen, S.,Elzey, B.D.,Skerlova, J.,Ajani, H.,Djukic, S.,Vojackova, V.,Lepsik, M.,Rezacova, P.,Krystof, V.,Jorda, R.,Sintim, H.O.; 3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo.; J.Med.Chem., 64:10981-10996, 2021; PubMed: 34288692; DOI: 10.1021/acs.jmedchem.1c00330

実験手法

X-RAY DIFFRACTION (2.54 Å)