7B7I

BAZ2A bromodomain in complex with triazole compound MS04-TN02

Summary for 7B7I

Entry DOI	10.2210/pdb7b7i/pdb
Related	7B7B 7B7G
Descriptor	Bromodomain adjacent to zinc finger domain protein 2A, 2-[4-[[(~{E})-~{N},~{N}'-dimethylcarbamimidoyl]amino]piperidin-1-yl]-~{N}-[[2-(3-methyl-1,2,3-triazol-4-yl)-1~{H}-benzimidazol-5-yl]methyl]ethanamide (3 entities in total)
Functional Keywords	four helical bundle, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	12802.40
Authors	Dalle Vedove, A.,Cazzanelli, G.,Sedykh, M.,Caflisch, A.,Lolli, G. (deposition date: 2020-12-10, release date: 2021-10-20, Last modification date: 2024-01-31)
Primary citation	Dalle Vedove, A.,Cazzanelli, G.,Batiste, L.,Marchand, J.R.,Spiliotopoulos, D.,Corsi, J.,D'Agostino, V.G.,Caflisch, A.,Lolli, G. Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. Acs Med.Chem.Lett., 13:1434-1443, 2022 Cited by PubMed: 36105334 DOI: 10.1021/acsmedchemlett.2c00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation