7B5Q
Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e)
Summary for 7B5Q
Entry DOI | 10.2210/pdb7b5q/pdb |
EMDB information | 11823 11828 12042 |
Descriptor | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... (5 entities in total) |
Functional Keywords | kinase, protein complex, small molecules inhibitor, cdk-activating kinase, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 119873.40 |
Authors | Greber, B.J.,Remis, J.,Ali, S.,Nogales, E. (deposition date: 2020-12-05, release date: 2021-02-10, Last modification date: 2024-05-15) |
Primary citation | Greber, B.J.,Remis, J.,Ali, S.,Nogales, E. 2.5 angstrom -resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942. Biophys.J., 120:677-686, 2021 Cited by PubMed: 33476598DOI: 10.1016/j.bpj.2020.12.030 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.5 Å) |
Structure validation
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