7B17

SARS-CoV-spike RBD bound to two neutralising nanobodies.

Summary for 7B17

• Entry DOI: 10.2210/pdb7b17/pdb
• EMDB information: 11980
• Descriptor: Spike protein S1, SARS-CoV-2 neutralizing biparatopic nanobody VE,nanobody E from Lama glama,SARS-CoV-2 neutralizing biparatopic nanobody VE,nanobody E from Lama glama, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: spike glycoprotein, sars-cov-2, nanobody, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); More
• Total number of polymer chains: 2
• Total formula weight: 52225.58

Authors

Hallberg, B.M.,Das, H. (deposition date: 2020-11-23, release date: 2021-02-10, Last modification date: 2022-12-21)

• Primary citation: Koenig, P.A.,Das, H.,Liu, H.,Kummerer, B.M.,Gohr, F.N.,Jenster, L.M.,Schiffelers, L.D.J.,Tesfamariam, Y.M.,Uchima, M.,Wuerth, J.D.,Gatterdam, K.,Ruetalo, N.,Christensen, M.H.,Fandrey, C.I.,Normann, S.,Todtmann, J.M.P.,Pritzl, S.,Hanke, L.,Boos, J.,Yuan, M.,Zhu, X.,Schmid-Burgk, J.L.,Kato, H.,Schindler, M.,Wilson, I.A.,Geyer, M.,Ludwig, K.U.,Hallberg, B.M.,Wu, N.C.,Schmidt, F.I.; Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape; Science, 371:-, 2021; PubMed: 33436526; DOI: 10.1126/science.abe6230

Experimental method

ELECTRON MICROSCOPY (4.01 Å)