7AXJ

Crystal structure of the hPXR-LBD in complex with estradiol and clotrimazole

7AXJ の概要

• エントリーDOI: 10.2210/pdb7axj/pdb
• 分子名称: Nuclear receptor subfamily 1 group I member 2, 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, ESTRADIOL, ... (4 entities in total)
• 機能のキーワード: nuclear receptor hormone receptor pregnane x receptor, nuclear protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37364.68

構造登録者

Delfosse, V.,Granell, M.,Blanc, P.,Bourguet, W. (登録日: 2020-11-09, 公開日: 2021-01-13, 最終更新日: 2024-01-31)

• 主引用文献: Delfosse, V.,Huet, T.,Harrus, D.,Granell, M.,Bourguet, M.,Gardia-Parege, C.,Chiavarina, B.,Grimaldi, M.,Le Mevel, S.,Blanc, P.,Huang, D.,Gruszczyk, J.,Demeneix, B.,Cianferani, S.,Fini, J.B.,Balaguer, P.,Bourguet, W.; Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33361153; DOI: 10.1073/pnas.2020551118

実験手法

X-RAY DIFFRACTION (2.3 Å)