7AWQ

Structure of the thermostabilized EAAT1 cryst-E386Q mutant in complex with L-ASP, sodium ions and the allosteric inhibitor UCPH101

Summary for 7AWQ

Entry DOI	10.2210/pdb7awq/pdb
Descriptor	Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, SODIUM ION, ASPARTIC ACID, ... (5 entities in total)
Functional Keywords	excitatory amino acid transporter 1, human glutamate transporter, slc1a3, ion-coupling mechanism, transport protein, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	57250.28
Authors	Canul-Tec, J.C.,Legrand, P.,Reyes, N. (deposition date: 2020-11-08, release date: 2021-10-13, Last modification date: 2024-01-31)
Primary citation	Canul-Tec, J.C.,Kumar, A.,Dhenin, J.,Assal, R.,Legrand, P.,Rey, M.,Chamot-Rooke, J.,Reyes, N. The ion-coupling mechanism of human excitatory amino acid transporters. Embo J., 41:e108341-e108341, 2022 Cited by PubMed: 34747040 DOI: 10.15252/embj.2021108341 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.65 Å)

Structure validation