7AWL
Structure of the thermostabilized EAAT1 cryst-II mutant in complex with barium and the allosteric inhibitor UCPH101
Summary for 7AWL
Entry DOI | 10.2210/pdb7awl/pdb |
Descriptor | Excitatory amino acid transporter 1, Neutral amino acid transporter, Excitatory amino acid transporter, Transporter protein, 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile, BARIUM ION (3 entities in total) |
Functional Keywords | excitatory amino acid transporter 1, human glutamate transporter, slc1a3, ion-coupling mechanism, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57157.45 |
Authors | Canul-Tec, J.C.,Legrand, P.,Reyes, N. (deposition date: 2020-11-08, release date: 2021-10-13, Last modification date: 2024-01-31) |
Primary citation | Canul-Tec, J.C.,Kumar, A.,Dhenin, J.,Assal, R.,Legrand, P.,Rey, M.,Chamot-Rooke, J.,Reyes, N. The ion-coupling mechanism of human excitatory amino acid transporters. Embo J., 41:e108341-e108341, 2022 Cited by PubMed: 34747040DOI: 10.15252/embj.2021108341 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.7 Å) |
Structure validation
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