7AWD

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with garcinoic acid

Summary for 7AWD

Entry DOI	10.2210/pdb7awd/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, (2Z,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-1-benzopyran-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid, CITRIC ACID, ... (5 entities in total)
Functional Keywords	pparg, steroid hormone receptor, garcinoic acid, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	32989.38
Authors	Chaikuad, A.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-06, release date: 2020-11-25, Last modification date: 2024-01-31)
Primary citation	Willems, S.,Gellrich, L.,Chaikuad, A.,Kluge, S.,Werz, O.,Heering, J.,Knapp, S.,Lorkowski, S.,Schubert-Zsilavecz, M.,Merk, D. Endogenous vitamin E metabolites mediate allosteric PPAR gamma activation with unprecedented co-regulatory interactions. Cell Chem Biol, 28:1489-1500.e8, 2021 Cited by PubMed: 33989565 DOI: 10.1016/j.chembiol.2021.04.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.93 Å)

Structure validation