7AWC
Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with rosiglitazone
Summary for 7AWC
Entry DOI | 10.2210/pdb7awc/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), GLYCEROL, ... (4 entities in total) |
Functional Keywords | pparg, steroid hormone receptor, inhibitor, structural genomics consortium, sgc, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32485.69 |
Authors | Chaikuad, A.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-11-06, release date: 2020-11-25, Last modification date: 2024-01-31) |
Primary citation | Willems, S.,Gellrich, L.,Chaikuad, A.,Kluge, S.,Werz, O.,Heering, J.,Knapp, S.,Lorkowski, S.,Schubert-Zsilavecz, M.,Merk, D. Endogenous vitamin E metabolites mediate allosteric PPAR gamma activation with unprecedented co-regulatory interactions. Cell Chem Biol, 28:1489-1500.e8, 2021 Cited by PubMed: 33989565DOI: 10.1016/j.chembiol.2021.04.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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