7AWC

Crystal structure of Peroxisome proliferator-activated receptor gamma (PPARG)in complex with rosiglitazone

7AWC の概要

• エントリーDOI: 10.2210/pdb7awc/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), GLYCEROL, ... (4 entities in total)
• 機能のキーワード: pparg, steroid hormone receptor, inhibitor, structural genomics consortium, sgc, dna binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32485.69

構造登録者

Chaikuad, A.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-11-06, 公開日: 2020-11-25, 最終更新日: 2024-01-31)

• 主引用文献: Willems, S.,Gellrich, L.,Chaikuad, A.,Kluge, S.,Werz, O.,Heering, J.,Knapp, S.,Lorkowski, S.,Schubert-Zsilavecz, M.,Merk, D.; Endogenous vitamin E metabolites mediate allosteric PPAR gamma activation with unprecedented co-regulatory interactions.; Cell Chem Biol, 28:1489-1500.e8, 2021; PubMed: 33989565; DOI: 10.1016/j.chembiol.2021.04.019

実験手法

X-RAY DIFFRACTION (1.74 Å)