7AW5

Crystal structure of OXA-48 beta-lactamase in the complex with the inhibitor ID3

Summary for 7AW5

Entry DOI	10.2210/pdb7aw5/pdb
Descriptor	Beta-lactamase, CHLORIDE ION, 4-[(~{E})-[3-(4-chlorophenyl)-5-sulfanylidene-1~{H}-1,2,4-triazol-4-yl]iminomethyl]benzoic acid, ... (4 entities in total)
Functional Keywords	class d beta-lactamase, oxa-48, antibiotic, dimer, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	2
Total formula weight	56948.60
Authors	Pochetti, G.,Montanari, R.,Capelli, D.,Garofalo, B.,Ombrato, R. (deposition date: 2020-11-06, release date: 2021-07-21, Last modification date: 2024-01-31)
Primary citation	Garofalo, B.,Prati, F.,Buonfiglio, R.,Coletta, I.,D'Atanasio, N.,Molteni, A.,Carettoni, D.,Wanke, V.,Pochetti, G.,Montanari, R.,Capelli, D.,Milanese, C.,Di Giorgio, F.P.,Ombrato, R. Discovery of Novel Chemical Series of OXA-48 beta-Lactamase Inhibitors by High-Throughput Screening. Pharmaceuticals, 14:-, 2021 Cited by PubMed: 34202402 DOI: 10.3390/ph14070612 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation