7AVX
MerTK kinase domain in complex with NPS-1034
Summary for 7AVX
Entry DOI | 10.2210/pdb7avx/pdb |
Descriptor | Tyrosine-protein kinase Mer, 1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | tyrosine kinase, inhibitor, type1.5 kinase inhibitor, type2 kinase inhibitor, structure-based drug design, oncology, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72881.95 |
Authors | Schimpl, M.,Nissink, J.W.M.,Blackett, C.,Goldberg, K.,Hennessy, E.J.,Hardaker, E.,McCoull, W.,McMurray, L.,Collingwood, O.,Overman, R.,Pflug, A.,Preston, M.,Rawlins, P.,Rivers, E.,Smith, P.,Underwood, E.,Truman, C.,Warwicker, J.,Winter, J.,Woodcock, S. (deposition date: 2020-11-06, release date: 2021-03-03, Last modification date: 2024-05-01) |
Primary citation | Nissink, J.W.M.,Bazzaz, S.,Blackett, C.,Clark, M.A.,Collingwood, O.,Disch, J.S.,Gikunju, D.,Goldberg, K.,Guilinger, J.P.,Hardaker, E.,Hennessy, E.J.,Jetson, R.,Keefe, A.D.,McCoull, W.,McMurray, L.,Olszewski, A.,Overman, R.,Pflug, A.,Preston, M.,Rawlins, P.B.,Rivers, E.,Schimpl, M.,Smith, P.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,Woodcock, S.,Zhang, Y. Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J.Med.Chem., 64:3165-3184, 2021 Cited by PubMed: 33683117DOI: 10.1021/acs.jmedchem.0c01904 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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