7AVX

MerTK kinase domain in complex with NPS-1034

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tyrosine-protein kinase Mer	polymer	313	35889.4	2	UniProt (Q12866) Pfam (PF07714) In PDB	Homo sapiens (Human)	Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK
2	A, B	1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide	non-polymer		551.5	2	Chemie (S4K)
3		water	water		18.0	97	Chemie (HOH)

Sequence modifications

A, B: 570 - 864 (UniProt: Q12866)

PDB	External Database	Details
Met 552	-	initiating methionine
Gly 553	-	expression tag
Ser 554	-	expression tag
Ser 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
His 559	-	expression tag
His 560	-	expression tag
His 561	-	expression tag
Ser 562	-	expression tag
Ser 563	-	expression tag
Gly 564	-	expression tag
Leu 565	-	expression tag
Val 566	-	expression tag
Pro 567	-	expression tag
Arg 568	-	expression tag
Gly 569	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71778.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1103.1
All*	Total formula weight	72882.0

*Water molecules are not included.