7AVM
Crystal Structure of Pro-Rhodesain C150A
Summary for 7AVM
Entry DOI | 10.2210/pdb7avm/pdb |
Descriptor | Cysteine protease, GLYCEROL (3 entities in total) |
Functional Keywords | african trypanosomes, sleeping sickness, human african trypanosomiasis, cysteine protease, zymogen, pro-enzyme, rhodesain, hydrolase |
Biological source | Trypanosoma brucei rhodesiense |
Total number of polymer chains | 1 |
Total formula weight | 35990.02 |
Authors | Johe, P.,Jaenicke, E.,Neuweiler, H.,Schirmeister, T.,Kersten, C.,Hellmich, U. (deposition date: 2020-11-05, release date: 2020-11-25, Last modification date: 2024-01-31) |
Primary citation | Johe, P.,Jaenicke, E.,Neuweiler, H.,Schirmeister, T.,Kersten, C.,Hellmich, U.A. Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes. J.Biol.Chem., 296:100565-100565, 2021 Cited by PubMed: 33745969DOI: 10.1016/j.jbc.2021.100565 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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