7AVM

Crystal Structure of Pro-Rhodesain C150A

Summary for 7AVM

Entry DOI	10.2210/pdb7avm/pdb
Descriptor	Cysteine protease, GLYCEROL (3 entities in total)
Functional Keywords	african trypanosomes, sleeping sickness, human african trypanosomiasis, cysteine protease, zymogen, pro-enzyme, rhodesain, hydrolase
Biological source	Trypanosoma brucei rhodesiense
Total number of polymer chains	1
Total formula weight	35990.02
Authors	Johe, P.,Jaenicke, E.,Neuweiler, H.,Schirmeister, T.,Kersten, C.,Hellmich, U. (deposition date: 2020-11-05, release date: 2020-11-25, Last modification date: 2024-01-31)
Primary citation	Johe, P.,Jaenicke, E.,Neuweiler, H.,Schirmeister, T.,Kersten, C.,Hellmich, U.A. Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes. J.Biol.Chem., 296:100565-100565, 2021 Cited by PubMed: 33745969 DOI: 10.1016/j.jbc.2021.100565 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation