7AUV

The structure of ERK2 in complex with dual inhibitor ASTX029

Summary for 7AUV

Entry DOI	10.2210/pdb7auv/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	mitogen activated kinase atp binding protein phosphorylation serine/threonine protein kinase, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43502.28
Authors	O'Reilly, M. (deposition date: 2020-11-03, release date: 2021-10-06, Last modification date: 2021-10-13)
Primary citation	Munck, J.M.,Berdini, V.,Bevan, L.,Brothwood, J.L.,Castro, J.,Courtin, A.,East, C.,Ferraldeschi, R.,Heightman, T.D.,Hindley, C.J.,Kucia-Tran, J.,Lyons, J.F.,Martins, V.,Muench, S.,Murray, C.W.,Norton, D.,O'Reilly, M.,Reader, M.,Rees, D.C.,Rich, S.J.,Richardson, C.J.,Shah, A.D.,Stanczuk, L.,Thompson, N.T.,Wilsher, N.E.,Woolford, A.J.,Wallis, N.G. ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK. Mol.Cancer Ther., 20:1757-1768, 2021 Cited by PubMed: 34330842 DOI: 10.1158/1535-7163.MCT-20-0909 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation