7AU5

Tubulin-noscapine-analogue-14e complex

7AU5 の概要

• エントリーDOI: 10.2210/pdb7au5/pdb
• 分子名称: Tubulin alpha-1B chain, GLYCEROL, (5~{R})-5-[(1~{S})-4,5-dimethoxy-1,3-dihydro-2-benzofuran-1-yl]-~{N}-ethyl-4-methoxy-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxamide, ... (14 entities in total)
• 機能のキーワード: cell cycle, tubulin fold, cytoskeleton, microtubule
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 265204.11

構造登録者

Yong, C.,Devine, S.M.,Abel, A.-C.,Muthiah, D.,Gao, X.,Callaghan, R.,Capuano, B.,Steinmetz, M.O.,Prota, A.E.,Scammels, P.J. (登録日: 2020-11-02, 公開日: 2021-07-07, 最終更新日: 2024-01-31)

• 主引用文献: Yong, C.,Devine, S.M.,Abel, A.C.,Tomlins, S.D.,Muthiah, D.,Gao, X.,Callaghan, R.,Steinmetz, M.O.,Prota, A.E.,Capuano, B.,Scammells, P.J.; 1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure.; Chemmedchem, 16:2882-2894, 2021; PubMed: 34159741; DOI: 10.1002/cmdc.202100363

実験手法

X-RAY DIFFRACTION (2.2 Å)