7ATV
Structure of protein kinase ck2 catalytic subunit (csnk2a2 gene product) in complex with the bivalent inhibitor KN2
Summary for 7ATV
Entry DOI | 10.2210/pdb7atv/pdb |
Related | 7AT5 |
Descriptor | Casein kinase II subunit alpha', 1,2-ETHANEDIOL, ~{N}'-[2-(3,4-dichlorophenyl)ethyl]-~{N}-[4-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]butyl]butanediamide, ... (5 entities in total) |
Functional Keywords | protein kinase ck2, casein kinase 2, bivalent inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43754.36 |
Authors | Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Goetz, C.,Jose, J.,Niefind, K. (deposition date: 2020-10-31, release date: 2021-08-04, Last modification date: 2022-02-09) |
Primary citation | Lindenblatt, D.,Applegate, V.,Nickelsen, A.,Klussmann, M.,Neundorf, I.,Gotz, C.,Jose, J.,Niefind, K. Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J.Med.Chem., 65:1302-1312, 2022 Cited by PubMed: 34323071DOI: 10.1021/acs.jmedchem.1c00063 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (0.98 Å) |
Structure validation
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