7ASC

TGFBIp mutant A546T

Summary for 7ASC

• Entry DOI: 10.2210/pdb7asc/pdb
• Related: 5nv6
• Descriptor: Transforming growth factor-beta-induced protein ig-h3 (1 entity in total)
• Functional Keywords: granular corneal dystrophy, lattice corneal dystrophy, protein aggregation, extracellular matrix protein, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 130246.73

Authors

Andersen, G.R.,Nielsen, N.S.,Gadeberg, T.A.F. (deposition date: 2020-10-27, release date: 2020-12-23, Last modification date: 2024-01-31)

• Primary citation: Nielsen, N.S.,Gadeberg, T.A.F.,Poulsen, E.T.,Harwood, S.L.,Weberskov, C.E.,Pedersen, J.S.,Andersen, G.R.,Enghild, J.J.; Mutation-induced dimerization of transforming growth factor-beta-induced protein may drive protein aggregation in granular corneal dystrophy.; J.Biol.Chem., 297:100858-100858, 2021; PubMed: 34097874; DOI: 10.1016/j.jbc.2021.100858

Experimental method

X-RAY DIFFRACTION (4.8 Å)