7AS0

Influenza A PB2 in complex with VX-787

Summary for 7AS0

Entry DOI	10.2210/pdb7as0/pdb
Descriptor	Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, BROMIDE ION, ... (4 entities in total)
Functional Keywords	influenza a, polymerase, cap-snatching, pb2, vx787, viral protein
Biological source	Influenza A virus (A/California/07/2009(H1N1))
Total number of polymer chains	1
Total formula weight	19123.74
Authors	Radilova, K.,Brynda, J. (deposition date: 2020-10-26, release date: 2021-02-24, Last modification date: 2024-01-31)
Primary citation	Gregor, J.,Radilova, K.,Brynda, J.,Fanfrlik, J.,Konvalinka, J.,Kozisek, M. Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase. Molecules, 26:-, 2021 Cited by PubMed: 33673017 DOI: 10.3390/molecules26041007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation