7ARX

Crystal structure of the catalytic fragment of masp-1 in complex with SFMI1

7ARX の概要

• エントリーDOI: 10.2210/pdb7arx/pdb
• 分子名称: Mannan-binding lectin serine protease 1, SFMI1 - Sunflower MASP1 inhibitor, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
• 機能のキーワード: protease, inhibitor, complex, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 47114.96

構造登録者

Durvanger, Z.,Harmat, V.,Dobo, J.,Megyeri, M. (登録日: 2020-10-26, 公開日: 2021-11-03, 最終更新日: 2024-01-31)

• 主引用文献: Durvanger, Z.,Boros, E.,Nagy, Z.A.,Hegedus, R.,Megyeri, M.,Dobo, J.,Gal, P.,Schlosser, G.,Angyan, A.F.,Gaspari, Z.,Perczel, A.,Harmat, V.,Mezo, G.,Menyhard, D.K.,Pal, G.; Directed Evolution-Driven Increase of Structural Plasticity Is a Prerequisite for Binding the Complement Lectin Pathway Blocking MASP-Inhibitor Peptides.; Acs Chem.Biol., 17:969-986, 2022; PubMed: 35378038; DOI: 10.1021/acschembio.2c00114

実験手法

X-RAY DIFFRACTION (2.42 Å)