7ARO

Crystal structure of the non-ribose partial agonist LUF5833 bound to the adenosine A2A receptor

7ARO の概要

• エントリーDOI: 10.2210/pdb7aro/pdb
• 分子名称: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, 2-azanyl-6-(1~{H}-imidazol-2-ylmethylsulfanyl)-4-phenyl-pyridine-3,5-dicarbonitrile, OLEIC ACID, ... (6 entities in total)
• 機能のキーワード: g protein-coupled receptor, gpcr, receptor, partial agonist, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49868.62

構造登録者

Verdon, G.,Amelia, T.,van Veldhoven, J.,Falsini, M.,Liu, R.,Heitman, L.,van Westen, G.,Segala, E.,Cheng, R.,Cooke, R.,van der Es, D.,Ijzerman, A. (登録日: 2020-10-25, 公開日: 2021-04-07, 最終更新日: 2024-01-31)

• 主引用文献: Amelia, T.,van Veldhoven, J.P.D.,Falsini, M.,Liu, R.,Heitman, L.H.,van Westen, G.J.P.,Segala, E.,Verdon, G.,Cheng, R.K.Y.,Cooke, R.M.,van der Es, D.,IJzerman, A.P.; Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A 2A Receptor.; J.Med.Chem., 64:3827-3842, 2021; PubMed: 33764785; DOI: 10.1021/acs.jmedchem.0c01856

実験手法

X-RAY DIFFRACTION (3.119 Å)