7AQF

Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab)

7AQF の概要

• エントリーDOI: 10.2210/pdb7aqf/pdb
• 分子名称: Plasminogen activator inhibitor 1, 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid (3 entities in total)
• 機能のキーワード: plasminogen activator inhibitor-1, pai-1, pai-1-stab, serpin, protease inhibitor, serine protease inhibitor, small molecule inhibitor, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85886.79

構造登録者

Sillen, M.,Strelkov, S.V.,Declerck, P.J. (登録日: 2020-10-21, 公開日: 2021-02-17, 最終更新日: 2024-01-31)

• 主引用文献: Sillen, M.,Miyata, T.,Vaughan, D.E.,Strelkov, S.V.,Declerck, P.J.; Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.; Int J Mol Sci, 22:-, 2021; PubMed: 33540702; DOI: 10.3390/ijms22031482

実験手法

X-RAY DIFFRACTION (1.77 Å)